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Year Number of Results
2003 1
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2010 1
2011 1
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Page 1
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Walker KR, Kang EL, Whalen MJ, Shen Y, Tesco G. Walker KR, et al. J Neurosci. 2012 Jul 25;32(30):10423-37. doi: 10.1523/JNEUROSCI.5491-11.2012. J Neurosci. 2012. PMID: 22836275 Free PMC article.
We further demonstrated the role of GGA3 in the regulation of BACE1 in vivo by showing that BACE1 levels are increased in the brain of GGA3-null mice. ...Moreover, GGA1 silencing potentiates BACE1 elevation induced by GGA3 deletion in neu …
We further demonstrated the role of GGA3 in the regulation of BACE1 in vivo by showing that BACE1 levels are increased …
Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer's disease trigger BACE1 accumulation in axonal swellings.
Lomoio S, Willen R, Kim W, Ho KZ, Robinson EK, Prokopenko D, Kennedy ME, Tanzi RE, Tesco G. Lomoio S, et al. Sci Transl Med. 2020 Nov 18;12(570):eaba1871. doi: 10.1126/scitranslmed.aba1871. Sci Transl Med. 2020. PMID: 33208500 Free PMC article.
We show that BACE pharmacological inhibition ameliorates BACE1 axonal trafficking and diminishes axonal dystrophies in Gga3 null neurons in vitro and in vivo. These data indicate that axonal accumulation of BACE1 engendered by GGA3 loss of function res …
We show that BACE pharmacological inhibition ameliorates BACE1 axonal trafficking and diminishes axonal dystrophies in Gga3 nu …
BACE1 elevation engendered by GGA3 deletion increases beta-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice.
Kim W, Ma L, Lomoio S, Willen R, Lombardo S, Dong J, Haydon PG, Tesco G. Kim W, et al. Mol Neurodegener. 2018 Feb 2;13(1):6. doi: 10.1186/s13024-018-0239-7. Mol Neurodegener. 2018. PMID: 29391027 Free PMC article.
GGA3 depletion results in BACE1 stabilization both in vitro and in vivo. ...GGA3 deletion prevented age-dependent elevation of BACE1 in GGA3KO;5XFAD mice. ...
GGA3 depletion results in BACE1 stabilization both in vitro and in vivo. ...GGA3 deletion prevented age-dependent eleva …
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M. Sarajärvi T, et al. J Biol Chem. 2009 Dec 4;284(49):34433-43. doi: 10.1074/jbc.M109.036202. Epub 2009 Oct 8. J Biol Chem. 2009. PMID: 19815556 Free PMC article.
Increased caspase-3 activity coincided with a significant depletion of the BACE1-sorting protein, GGA3 (Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein), and subsequently augmented BACE1 protein levels and activity. ...These adver …
Increased caspase-3 activity coincided with a significant depletion of the BACE1-sorting protein, GGA3 (Golgi-localized gamma- …
Ubiquitin regulates GGA3-mediated degradation of BACE1.
Kang EL, Cameron AN, Piazza F, Walker KR, Tesco G. Kang EL, et al. J Biol Chem. 2010 Jul 30;285(31):24108-19. doi: 10.1074/jbc.M109.092742. Epub 2010 May 18. J Biol Chem. 2010. PMID: 20484053 Free PMC article.
Here, we report that the accumulation of BACE1 is rescued by the ectopic expression of GGA3 in H4 neuroglioma cells depleted of GGA3. Accordingly, the overexpression of GGA3 reduces the levels of BACE1 and beta-amyloid. We then established that …
Here, we report that the accumulation of BACE1 is rescued by the ectopic expression of GGA3 in H4 neuroglioma cells depleted o …
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, Sarajärvi T, Mäkinen P, Kurkinen KM, Mullin K, Alafuzoff I, Haapasalo A, Bertram L, Soininen H, Tanzi RE, Hiltunen M. Natunen T, et al. J Alzheimers Dis. 2013;37(1):217-32. doi: 10.3233/JAD-130104. J Alzheimers Dis. 2013. PMID: 23970038
Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degradation of BACE1 (beta-site AbetaPP-cleaving enzyme), the rate-limiting enzyme in the production of amyloid-beta (Abeta) in Alzheimer's …
Golgi-localized gamma-ear-containing ADP-ribosylation factor-binding protein (GGA3) is a central regulator of trafficking and degrada …
Genetic Deletion of the Clathrin Adaptor GGA3 Reduces Anxiety and Alters GABAergic Transmission.
Walker KR, Modgil A, Albrecht D, Lomoio S, Haydon PG, Moss SJ, Tesco G. Walker KR, et al. PLoS One. 2016 May 18;11(5):e0155799. doi: 10.1371/journal.pone.0155799. eCollection 2016. PLoS One. 2016. PMID: 27192432 Free PMC article.
We further demonstrated the role of GGA3 in the regulation of BACE1 in vivo by showing that BACE1 levels are increased in the brain of GGA3 null mice. ...Since BACE1 levels are elevated in the brain of GGA3 null mice, it is possible that …
We further demonstrated the role of GGA3 in the regulation of BACE1 in vivo by showing that BACE1 levels are increased …
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.
Tesco G, Koh YH, Kang EL, Cameron AN, Das S, Sena-Esteves M, Hiltunen M, Yang SH, Zhong Z, Shen Y, Simpkins JW, Tanzi RE. Tesco G, et al. Neuron. 2007 Jun 7;54(5):721-37. doi: 10.1016/j.neuron.2007.05.012. Neuron. 2007. PMID: 17553422 Free PMC article.
RNAi silencing of GGA3 also elevated levels of BACE and Abeta. Finally, in AD brain samples, GGA3 protein levels were significantly decreased and inversely correlated with increased levels of BACE. In summary, we have elucidated a GGA3-dependent mechanism reg …
RNAi silencing of GGA3 also elevated levels of BACE and Abeta. Finally, in AD brain samples, GGA3 protein levels were signific …
The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation.
Yeates EF, Tesco G. Yeates EF, et al. J Biol Chem. 2016 Jul 22;291(30):15753-66. doi: 10.1074/jbc.M116.718023. Epub 2016 Jun 14. J Biol Chem. 2016. PMID: 27302062 Free PMC article.
Our previous studies have shown that BACE1 is degraded via the lysosomal pathway and that that depletion of the trafficking molecule Golgi-localized gamma-ear-containing ARF-binding protein 3 (GGA3) results in increased BACE1 levels and activity because of im …
Our previous studies have shown that BACE1 is degraded via the lysosomal pathway and that that depletion of the trafficking molecule …
Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.
Tan J, Evin G. Tan J, et al. J Neurochem. 2012 Mar;120(6):869-80. doi: 10.1111/j.1471-4159.2011.07623.x. Epub 2012 Jan 23. J Neurochem. 2012. PMID: 22171895 Free article. Review.
Phosphorylation of Ser498 facilitates BACE1 recognition by GGA1 for retrieval to the endosome. Ubiquitination of BACE1 C-terminal Lys501 signals GGA3 for exporting BACE1 to the lysosome for degradation. ...Decreased levels of GGA3 also impair …
Phosphorylation of Ser498 facilitates BACE1 recognition by GGA1 for retrieval to the endosome. Ubiquitination of BACE1 C-termi …
21 results